How does SARS-CoV-2 evade the immune defences?

As most of pathogens, SARS-CoV-2 can be recognized by pattern recognition receptors on innate. Normally, this recognition helps the innate immunity to eliminate the infection or to activate the adaptive immune responses, however, SARS-CoV-2 can use its proteins such as M, N, NSP1 and PLpro to interfere with these pathways.

The battle between host and SARS-CoV-2: Innate immunity and viral evasion strategies: Molecular Therapy

How SARS-CoV-2 evades immune system defenses — Harvard Gazette

Innate immune evasion strategies of SARS-CoV-2

IJMS, Free Full-Text

Frontiers Innate Immune Responses to Highly Pathogenic Coronaviruses and Other Significant Respiratory Viral Infections

Information for Persons Who Are Immunocompromised Regarding Prevention and Treatment of SARS-CoV-2 Infection in the Context of Currently Circulating Omicron Sublineages — United States, January 2023

SARS-CoV-2 spike mutation L452R evades human

Does COVID really damage your immune system and make you more vulnerable to infections? The evidence is lacking

Viruses, Free Full-Text

Infection and pathogenesis of SARS-CoV2: an immunological perspective, Book

The molecular mechanism of SARS-CoV-2 evading host antiviral innate immunity, Virology Journal

How COVID-19 variants evade immune response

Frontiers SARS-CoV-2 Variants, Vaccines, and Host Immunity